Similarly, loss of maternal-zygotic PRMT5 also leads to IAP upregulation. Here we show that conditional loss of PRMT5 in early PGCs causes complete male and female sterility, preceded by the upregulation of LINE1 and IAP transposons as well as activation of a DNA damage response. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process.
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which includes comprehensive DNA demethylation.
